Originally from Mexico, Dr. Martinez and his parents immigrated to the United States when he was six years old. He grew up in San Antonio, TX. Though initially interested in the neurosciences, he became involved in thoracic surgery research involving explanted lungs and bronchial stents in the laboratory of Dr. Joel Cooper at Washington University.
Education:
MD, Washington University in St. Louis School of Medicine – 2005
Other Postgraduate Training:
2005-present: U. of TX Health Science Center, San Antonio, TX. General Surgery Residency Program
2007-2008: U. of TX Health Science Center, San Antonio, TX. Masters of Science in Clinical Investigation Program
2001-2002: Washington Univ. School of Medicine, St. Louis, MO. Graduate Research – Spinal cord injury repair
Publications:
Martinez CO, McHale MJ, Ochoa O, Michalek JE, McManus LM, Shireman PK. Regulation of skeletal muscle regeneration and angiogenesis by CCR2-activating chemokines is directly related to macrophage recruitment. Am J Physiol Regul Integr Comp Physiol 299:832-42, 2010.
Prajapati SI, Martinez CO, Abraham J, McCleish AT, Michalek JE, McManus LM, Rubin BP, Shireman PK, Keller C. Crimson carrier, A long-acting contrast agent for in vivo near-infrared imaging of injured and diseased muscle. Muscle Nerve.
Prajapati SI, Martinez CO, Bahadur AN, Wu IQ, Zheng W, Lechleiter JD, McManus LM, Chisholm GB, Michalek JA, Shireman PK, Keller C. Near-infrared imaging of injured tissue in living subjects using IR-820. Molecular Imaging 8:45-54, 2009.
Sun D, Martinez CO, Ochoa O, Ruiz-Willhite L, Bonilla JR, Centonze VE, Waite LL, Michalek JE, McManus LM, Shireman PK. Bone marrow-derived cell regulation of skeletal muscle regeneration. FASEB J 23:382-95, 2009.
Choong CK, Macklem PT, Pierce JA, Das N, Lutey BA, Martinez CO, Cooper JD: Airway bypass improves the mechanical properties of explanted emphysematous lungs. Am J Respir Crit Care Med 178:902-5, 2008.
Choong CK, Martinez C, Barner HB: Chylothorax after internal thoracic artery harvest. Ann Thorac Surg 81:1507-9, 2006.
Choong CK, Phan L, Massetti P, Haddad FJ, Martinez C, Roschak E, Cooper JD: Prolongation of patency of airway bypass stents with use of drug-eluting stents. J Thorac Cardiovasc Surg 131:60-4, 2006.
Choong CK, Haddad FJ, Martinez C, Hu DZ, Pierce JA, Meyers BF, Patterson GA, Cooper JD: A simple, reproducible, and inexpensive technique in the preparation of explanted emphysematous lungs for ex vivo studies. J Thorac Cardiovasc Surg 130:922-3, 2005.
Martinez CO, Do VH, Martinez JL, Derrick BE: Associative long-term potentiation (LTP) among extrinsic afferents of the hippocampal CA3 region in vivo. Brain Res 940(1-2):86-94, 2002.
Do VH, Martinez CO, Martinez JL Jr, Derrick BE: Long-term potentiation in direct perforant path projections to the hippocampal CA3 region in vivo. J Neurophysiol 87(2):669-78, 2002.
Chapters:
Shireman PK, Martinez CO. Chapter 7. Arteriogenesis, Rutherford’s Textbook of Vascular Surgery, 7th edition.
Presentations:
Martinez CO, McManus LM, Shireman PK. Kinetics of myogenic progenitor cell (MPC) expansion and bone marrow-derived cell recruitment in skeletal muscle regeneration. Experimental Biology, New Orleans, LA, 2009.
Martinez CO, Sun D, Waite LL, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration by CCR2-activating chemokines and in vivo characteristics of myogenic progenitor cells. San Antonio Vascular Surgical Society Conference, San Antonio, TX, 2008.
Ochoa O, Martinez CO, Torres FM, Ruiz-Willhite L, Michalek JE, McManus LM, Shireman PK. Differential regulation of skeletal muscle regeneration and angiogenesis by CCR2-activating chemokines. J Surg Res 144(2):218, 2008, 2008 Academic Surgical Congress.
Rosenzweig ES, Becker D, Martinez C, Grill WM, McDonald JW, Functional Electrical Stimulation After Spinal Cord Injury Promotes Cell Birth And Neuronal Differentiation Of Transplanted Embryonic Stem Cells, Neural Regeneration Symposium, Pacific Grove, CA, 2003.
Martinez CO, Liu S, Qu Y, McDonald JW, Embryonic Stem Cell-Derived Oligodendrocytes Survive, Proliferate, And Myelinate Dorsal Root Ganglion Axons, Society for Neuroscience Annual Conference, Orlando, FL, 2002.
Research:
1996-1998: Minority Access to Research Careers (MARC): NIH program introducing students from disadvantaged groups to academic research. The goals of this study focused on cellular and molecular mechanisms of potentiation, depression, and neurocomputation research in learning and memory pathways in the lab of Dr. Brian Derrick.
1998-1999: Minority Biomedical Research Support (MBRS): NIH program to increase underrepresented minority groups in biomedical sciences. The program supported research in the Derrick lab and funded travel opportunities to interview for graduate programs.
2001-2002: Howard Hughes Medical Fellowship: Competitive medical student fellowship that funded research in Dr. John McDonald’s lab working in spinal cord injury, repair, and embryonic stem cell research.
2007-2009: NIH Postdoctoral Research Fellowship: F32 HL090196 Angiogenesis, macrophages, and tissue recovery from injury. This proposal tests the hypothesis that recruitment and activation of monocytes/macrophages are essential for angiogenesis and the normal regeneration of muscle after injury.
2007-2009: NIH Loan Repayment Program: Health Disparities Research. The major goals of this study are to determine the effects of (1) early vs. late monocyte/macrophage ablation on angiogenesis and muscle regeneration; (2) monocyte/macrophage ablation on neutrophil and myogenic progenitor cell accumulation; and (3) monocyte/macrophage ablation on tissue and plasma levels of MCP-1 and VEGF.
Awards, Honors:
2010, Looking to the Future Scholarship. Society of Thoracic Surgeons Annual Meeting, 2010.
2009, American Society for Investigative Pathology Trainee Travel Award. Experimental Biology Conference, 2009.
2008, 2nd Place, San Antonio Vascular Surgical Society Resident Research competition
2008, Selected as Resident Reviewer for the Archives of Surgery Residents Forum
2001-2002, Howard Hughes Medical Fellowship, Washington U. School of Medicine, St. Louis, MO.
In the news:
Carlo Martinez, MD, General Surgery Resident, visits Will Rogers Elementary School for their “Read Across America” activities: In February 2010, Dr. Martinez was asked to speak to fifth graders at Will Ross Elementary. His talk focused on Learning and Memory – showing the students that how they study and prepare for their TAKS testing is not very different from how a surgeon studies and prepares for caring for his patients. (3-5-10)